Endocrine Disorders;Case Study

Endocrine Disorders.

Endocrine Disorders
Endocrine Disorders

Share a case study from your clinical practice or from the literature on an Endocrine Disorders.

Discuss the psychopathology of the disorder, including the effects on the endocrine feedback system, and the role of the hypothalamic-pituitary axis.

Identify the pharmacologic agent(s) used to treat the disorder and how the pharmacologic agent(s) alters the psychopathology.

Mesenchymal Stem Cell Research

Mesenchymal Stem.

Mesenchymal Stem
Mesenchymal Stem

I would like to start an immediate job of researching disease in which there are mesenchymal stem (or stromal) cell (MSC) dysfunction.

I have found papers that show MSCs from patients and diabetic mice show functional deficits and can’t be used for MSC transplants.

I would to assemble a collection of all papers from any disease that shows MSC deficits/changes.

I would also like a table summarizing the disease, MSC source, documented changes, and how they determined the changes (procedure).

If you are interested, send me a quote for the job based on how long you think this will take. I prefer an agreed upon upfront price.

This job was posted from a mobile device, so please pardon any typos or any missing details.

Pathophysiology; Tim’s Case

Pathophysiology.

Pathophysiology
Pathophysiology

Tim’s Pathophysiology Case;

Tim goes to his family physician complaining of;
  • worsening angina,
  • shortness of breath, and
  • extreme fatigue.
Tim is;
  • 5’11”,
  • 240 lbs, and
  • 68 years old.

He has a history of smoking (one pack a day for 40 years), and is on the verge of Type II diabetes.

Tim has been previously diagnosed with atherosclerosis, and has had bypass surgery to correct 2 blocked coronary arteries.

A year ago, Tim had a heart attack and spent a couple of months in the hospital, during which he quit smoking.

Tim is retired, and leads a virtually sedentary lifestyle. He goes for a walk with his wife one or two times a week when she drags him out, but lately he’s been too tired even to do that.

He tries to watch what he eats – he avoids sweets most of the time, but still consumes a relatively high fat diet and has at least one beer every evening.

He’s a bit concerned about his condition, but apart from the occasional chest pain and fatigue, claims that he feels “just fine”.

Tim’s vitals at the doctor’s office are as follows:
  • HR 90 bpm; slightly irregular
  • BP 140/80
  • Respiration – slight tachypnea, shallow
His last blood work revealed the following:
  • Total cholesterol – 240 mg/dL
  • HDL – 31 mg/dL
  • LDL – 140 mg/dL
  • Fasting glucose – 100 mg/dL
  • Slightly elevated CRP
  • Slight hypernatremia

Further imaging has shown blockage in a new coronary vessel, and Tim wants to have another bypass surgery (this would mean he would have 3 total coronary arteries bypassed).

Is Tim a good candidate for bypass surgery? Why or why not? Give 3 reasons to support your answer. (4 pts)

Tim could also make lifestyle modifications – but he has not yet committed to making any major changes.

Describe how you could convince him to make those necessary changes to his lifestyle. (3 pts)

Do you think Tim’s health insurance should pay for this bypass surgery? Why or why not? (3 pts)